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Article

Transcription regulatory polymorphism -43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy.

Rheumatology international - 1 Sept 2007

Chatzikyriakidou Anthoula, Georgiou Ioannis, Voulgari Paraskevi V, Papadopoulos Christos G, Tzavaras Theodoros, Drosos Alexandros A

Abstract excerpt

The reduced folate carrier (RFC) protein (SLC19A1-gene) has central role in the uptake and intracellular accumulation of folates. In this respect, we investigate whether SLC19A1 genetic variations could affect rheumatoid arthritis (RA) patient response to antifolate treatment. One hundred six unrelated RA patients were enrolled in this study. Polymerase chain reaction (PCR)-single strand conformation polymorphism...

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Identifiers

PMID: 17404734
DOI: 10.1007/s00296-007-0339-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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