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Article

Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.

Journal of biochemical and molecular toxicology - 1 Aug 2020

Wang Jiayi, Yin Jun, Li Wei, Xiao Chunyuan, Han Jie, Zhou Fanfan

Abstract excerpt

Methotrexate (MTX), one of the important disease-modifying anti-rheumatic drugs, is the first-line drug for rheumatoid arthritis (RA) treatment. However, its adverse drug effects (ADEs) often lead to the abortion of MTX therapy. Human organic anion-transporting polypeptide 1A2 (OATP1A2, also referred as OATP-A or OATP1) encoded by SLCO1A2 gene is an important isoform of the solute carrier transporter (SLC)...

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PMID: 32304147
DOI: 10.1002/jbt.22513

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