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Article

Influence of RFC1 c.80A>G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis.

The Annals of pharmacotherapy - 1 Dec 2021

Naushad Shaik Mohammad, Alrokayan Salman A, Almajhdi Fahad N, Hussain Tajamul

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is an antirheumatic drug, transported by reduced folate carrier-1 (RFC1). The most common RFC1 gene variant, c.80 A>G (rs1051266) is ambiguously linked to adverse effects of MTX therapy in some rheumatoid arthritis (RA) patients. OBJECTIVE: The purpose of meta-analysis was to summarize all major published studies on c.80 A>G SNP to clarify this ambiguity in MTX therapy. METHODS: A...

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PMID: 33749319
DOI: 10.1177/10600280211002053

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