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Article

Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2014

Gotha Lara, Lim Sang Yup, Osherov Azriel B, Wolff Rafael, Qiang Beiping, Erlich Ilana, Nili Nafiseh, Pillarisetti Sivaram, Chang Ya-Ting, Tran Phan-Kiet, Tryggvason Karl, Hedin Ulf, Tran-Lundmark Karin, Advani Suzanne L, Gilbert Richard E, Strauss Bradley H

Abstract excerpt

Perlecan is a proteoglycan composed of a 470-kDa core protein linked to three heparan sulfate (HS) glycosaminoglycan chains. The intact proteoglycan inhibits the smooth muscle cell (SMC) response to vascular injury. Hspg2(Δ3/Δ3) (MΔ3/Δ3) mice produce a mutant perlecan lacking the HS side chains. The objective of this study was to determine differences between these two types of perlecan in modifying SMC...

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Identifiers

PMID: 24858854
DOI: 10.1152/ajpheart.00654.2013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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