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Cell Type Diversity in Hepatitis B Virus RNA Splicing and Its Regulation

8 Feb 2019

Abstract excerpt

Although RNA splicing of hepatitis B virus (HBV) is a commonly observed in livers of hepatitis B patients as well as in the cultured cells replicating the viral genome, its biological significance in the HBV life cycle and the detailed regulatory mechanisms are still largely unclear. In this study, we found cell-type dependency of HBV splicing of the 3.5 kb pregenomic RNA, which is efficiently spliced in human...

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Identifiers

PMID: 30800119
DOI: 10.3389/fmicb.2019.00207

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