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Article

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119

22 Apr 2016

Abstract excerpt

Primary cilia are sensory organelles indispensable for organogenesis and tissue pattern formation. Ciliopathy small GTPase ARLs are proposed as prominent ciliary switches, which when disrupted result in dysfunctional cilia, yet how ARLs are activated remain elusive. Here, we discover a novel small GTPase functional module, which contains ARL-3, ARL-13, and UNC-119, localizes near the poorly understood inversin...

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PMID: 27102355
DOI: 10.1038/srep24534

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