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Article

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption.

The Journal of clinical investigation - 2 Jul 2018

Salantes D Brenda, Zheng Yu, Mampe Felicity, Srivastava Tuhina, Beg Subul, Lai Jun, Li Jonathan Z, Tressler Randall L, Koup Richard A, Hoxie James, Abdel-Mohsen Mohamed, Sherrill-Mix Scott, McCormick Kevin, Overton E Turner, Bushman Frederic D, Learn Gerald H, Siliciano Robert F, Siliciano Janet M, Tebas Pablo, Bar Katharine J

Abstract excerpt

BACKGROUND: The effect of a brief analytical treatment interruption (ATI) on the HIV-1 latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic infection is unknown. METHODS: We evaluated the impact of transient viremia on the latent reservoir in participants who underwent an ATI and at least 6 months of subsequent viral suppression in a clinical trial testing the effect of passive...

Read the complete abstract on PubMed

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Share to Anti-Retroviral Agents
Share to Broadly Neutralizing Antibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, env

Share to HIV Antibodies

Share to HIV Envelope Protein gp160

Share to Proviruses

Share to Viremia

Share to Virus Latency

Source

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Identifiers

PMID: 29911997
DOI: 10.1172/JCI120194
PMCID: PMC6026010

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