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Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

1 Apr 2022

Abstract excerpt

The HIV-1 reservoir is composed of cells harboring latent proviruses that have the potential to contribute to viremia upon antiretroviral treatment (ART) interruption. While this reservoir is known to be maintained by clonal expansion of infected cells, the contribution of these cell clones to residual viremia and viral rebound remains underexplored. Here, we conducted an extensive analysis on four ART-treated...

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PMID: 35476994
DOI: 10.1016/j.celrep.2022.110739

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