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Relationship between intact HIV-1 proviruses in circulating CD4 + T cells and rebound viruses emerging during treatment interruption

12 Nov 2018

Abstract excerpt

Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented by a variety of methods, most prominently by viral outgrowth assays (VOAs) in which CD4 + T cells are activated to produce virus in vitro, or more recently by...

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PMID: 30420517
DOI: 10.1073/pnas.1813512115

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