Article
Virus evolution during chronic hepatitis B virus infection as revealed by ultradeep sequencing data.
The Journal of general virology - 1 Feb 2016
Jones Leandro R, Sede Mariano, Manrique Julieta M, Quarleri Jorge
Abstract excerpt
Despite chronic hepatitis B virus (HBV) infection (CHB) being a leading cause of liver cirrhosis and cancer, HBV evolution during CHB is not fully understood. Recent studies have indicated that virus diversity progressively increases along the course of CHB and that some virus mutations correlate with severe liver conditions such as chronic hepatitis, cirrhosis and hepatocellular carcinoma. Using ultradeep...
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