HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals.

doi:10.1016/j.antiviral.2020.104973

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Article

HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals.

Antiviral research - 1 Feb 2021

Glebe Dieter, Goldmann Nora, Lauber Chris, Seitz Stefan

Abstract excerpt

Hepatitis B virus (HBV) poses a major global health burden with 260 million people being chronically infected and 890,000 dying annually from complications in the course of the infection. HBV is a small enveloped virus with a reverse-transcribed DNA genome that infects hepatocytes and can cause acute and chronic infections of the liver. HBV is endemic in humans and apes representing the prototype member of the...

Topics

Animals
Antiviral Agents
Chiroptera
Evolution, Molecular
Genetic Variation
Genome, Viral
Genotype
Hepatitis B
Hepatitis B Vaccines
Hepatitis B virus
Hepatocytes
Humans
Primates
Virus Internalization
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 33166575
DOI: 10.1016/j.antiviral.2020.104973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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