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Article

Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2015

Noss Erika H, Nguyen Hung N, Chang Sook Kyung, Watts Gerald F M, Brenner Michael B

Abstract excerpt

Interleukin (IL)-6 blockade is an effective treatment for rheumatoid arthritis (RA), and synovial fibroblasts are a major IL-6 producer in the inflamed joint. We found that human RA and osteoarthritis (OA) synovial fibroblasts derived from independent donors reproducibly segregated into low, medium, and high IL-6 producers, independent of stimulus, cell passage, or disease state. IL-6 expression pattern...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26578807
DOI: 10.1073/pnas.1520861112
PMCID: PMC4672776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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