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Article

IL-6 polymorphisms: a useful genetic tool for inflammation research?

The Journal of clinical investigation - 1 Apr 2013

Woo Patricia, Humphries Steve E

Abstract excerpt

In 1998, we described a novel polymorphism in the promoter (G>C, rs1800795) of the IL-6 (IL6) gene. The common allele, G, exhibited higher transcriptional activity in gene reporter assays and was associated with higher serum IL-6 levels in a small cohort of healthy subjects. We explored the ethnic distribution of these alleles and found significant differences among people of mixed European descent, Africans, and...

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Identifiers

PMID: 23543063
DOI: 10.1172/JCI67221
PMCID: PMC3613933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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