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Osteoclasts—Key Players in Skeletal Health and Disease

6 May 2016

Abstract excerpt

The differentiation of osteoclasts (OCs) from early myeloid progenitors is a tightly regulated process that is modulated by a variety of mediators present in the bone microenvironment. Once generated, the function of mature OCs depends on cytoskeletal features controlled by an αvβ3-containing complex at the bone-apposed membrane and the secretion of protons and acid-protease cathepsin K. OCs also have important...

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PMID: 27337470
DOI: 10.1128/microbiolspec.mchd-0011-2015

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