Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in the mTOR pathway and breast cancer risk in African American women.

Carcinogenesis - 1 Jan 2016

Cheng Ting-Yuan David, Ambrosone Christine B, Hong Chi-Chen, Lunetta Kathryn L, Liu Song, Hu Qiang, Yao Song, Sucheston-Campbell Lara, Bandera Elisa V, Ruiz-Narváez Edward A, Haddad Stephen, Troester Melissa A, Haiman Christopher A, Bensen Jeannette T, Olshan Andrew F, Palmer Julie R, Rosenberg Lynn

Abstract excerpt

The phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (mTOR) pathway has been implicated in breast carcinogenesis. However, there has been no large-scale investigation of genetic variants in the mTOR pathway and breast cancer risk. We examined 28847 single-nucleotide polymorphisms (SNPs) in 61 mTOR pathway genes in the African American Breast Cancer Epidemiology and Risk consortium of 3663 cases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ductal, Breast

Share to Carcinoma in Situ

Share to Neoplasm Invasiveness

Share to Receptors, Estrogen

Share to Signal Transduction

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 26577839
DOI: 10.1093/carcin/bgv160
PMCID: PMC5006112

Genes

BRAF
MAPK3
PGF
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in the mTOR pathway and breast cancer risk in African American women.PMID 26577839Read ↗

Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.Semantic proximity Read ↗

Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American women.Semantic proximity Read ↗

Impacts of the mTOR gene polymorphisms rs2536 and rs2295080 on breast cancer risk in the Chinese population.Semantic proximity Read ↗

mTOR pathway candidate genes and obesity interaction on breast cancer risk in black women from the Women's Circle of Health Study.Semantic proximity Read ↗

Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis.Semantic proximity Read ↗

Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival.Semantic proximity Read ↗

Meta-analysis of the association between mTORC1-related genes polymorphisms and cancer risk.Semantic proximity Read ↗

mTOR pathway candidate genes and energy intake interaction on breast cancer risk in Black women from the Women's Circle of Health Study.Semantic proximity Read ↗

miRNA-767 and its binding site polymorphism in the mTOR gene act as potential biomarkers for female reproductive cancers.Semantic proximity Read ↗

mTOR pathway candidate genes and physical activity interaction on breast cancer risk in black women from the women's circle of health study.Semantic proximity Read ↗

Association of mTOR polymorphisms with cancer risk and clinical outcomes: a meta-analysis.Semantic proximity Read ↗

Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.