Article
Meta-analysis of the association between mTORC1-related genes polymorphisms and cancer risk.
Pathology, research and practice - 1 Jan 2022
Lu Xiaoling, Liu Meitong, Liao Yuxiao, Huang Chao, Chai Longlong, Jin Yuchen, Xiong Qiantao, Chen Bifeng
Abstract excerpt
BACKGROUND: mTOR, mLST8 and RAPTOR are the core components of mTORC1, which has been found to be closely related to tumorigenesis. Currently, multiple single nucleotide polymorphisms (SNPs) in mTOR gene (rs2295080, rs17036508 and rs1034528), mLST8 gene (rs3160 and rs26865) and RPTOR gene (rs1062935, , , ) have been extensively studied for their associations with cancer risk. However,...