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Article

Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival.

Breast cancer research and treatment - 1 Sept 2014

Pande Mala, Bondy Melissa L, Do Kim-Anh, Sahin Aysegul A, Ying Jun, Mills Gordon B, Thompson Patricia A, Brewster Abenaa M

Abstract excerpt

Obesity-related hormones and cytokines alter PI3 K-AKT-mTOR pathway activation in breast tumors contributing to poorer disease-free survival (DFS) and decreased responsiveness to tamoxifen and trastuzumab. We hypothesized that single nucleotide polymorphisms (SNPs) in candidate genes in the PI3 K-AKT-mTOR signaling pathway may act as genetic modifiers of breast cancer DFS. We analyzed the association of 106...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25108739
DOI: 10.1007/s10549-014-3081-9
PMCID: PMC4174407

Genes

ADIPOQ
IGF1
LEPR
TSC1
AKT1
INS
IRS1
LEP
LEPROT
PTEN
TSC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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