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miRNA-767 and its binding site polymorphism in the mTOR gene act as potential biomarkers for female reproductive cancers.

Future oncology (London, England) - 1 Sept 2023

Shafique Rabia, Mahjabeen Ishrat, Bibi Kashaf, Kalsoom Farah, Rizwan Muhammad, Ashraf Nida Sarosh, Mehmood Azhar, Ul Haq Maria Fazal, Abbasi Sumaira Fida, Saeed Nadia, Kayani Mahmood Akhtar

Abstract excerpt

Aims: The present study aimed to understand the relationship between the mTOR gene SNP (rs2536) and reproductive cancer risk. The expression level of miRNA-767 was also assessed. Methods: 700 tumor samples (300 breast, 200 ovarian and 200 cervical cancers), along with adjacent uninvolved control tissue, were used. rs2536 was screened using Tetra-ARMS PCR and expression level of miRNA-767 was assessed using...

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PMID: 37781867
DOI: 10.2217/fon-2022-1055

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