Article
Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data.
Nature genetics - 1 Jun 2003
Segal Eran, Shapira Michael, Regev Aviv, Pe'er Dana, Botstein David, Koller Daphne, Friedman Nir
Abstract excerpt
Much of a cell's activity is organized as a network of interacting modules: sets of genes coregulated to respond to different conditions. We present a probabilistic method for identifying regulatory modules from gene expression data. Our procedure identifies modules of coregulated genes, their regulators and the conditions under which regulation occurs, generating testable hypotheses in the form 'regulator X...
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