Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining.

Genome biology - 17 Nov 2015

Singer Mirko, Marshall Jennifer, Heiss Kirsten, Mair Gunnar R, Grimm Dirk, Mueller Ann-Kristin, Frischknecht Friedrich

Abstract excerpt

BACKGROUND: Genome editing of malaria parasites is key to the generation of live attenuated parasites used in experimental vaccination approaches. DNA repair in Plasmodium generally occurs only through homologous recombination. This has been used to generate transgenic parasites that lack one to three genes, leading to developmental arrest in the liver and allowing the host to launch a protective immune response....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to Deoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA End-Joining Repair

Share to Gene Deletion

Share to Genetic Variation

Share to Plasmodium berghei

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 26573820
DOI: 10.1186/s13059-015-0811-1
PMCID: PMC4647826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining.PMID 26573820Read ↗

DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparumSemantic proximity Read ↗

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.Semantic proximity Read ↗

Chromosome End Repair and Genome Stability in Plasmodium falciparum.Semantic proximity Read ↗

A replication-competent late liver stage–attenuated human malaria parasiteSemantic proximity Read ↗

Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 SystemSemantic proximity Read ↗

CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantumSemantic proximity Read ↗

Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liverSemantic proximity Read ↗

Cutting back malaria: CRISPR/Cas9 genome editing of PlasmodiumSemantic proximity Read ↗

CRISPR-mediated knock-in of transgenes into the malaria vector <i>Anopheles funestus</i>Semantic proximity Read ↗

Ribozyme-Mediated, Multiplex CRISPR Gene Editing and CRISPRi in <i>Plasmodium yoelii</i>Semantic proximity Read ↗

A Conditional Cas9 System for Stage-Specific Gene Editing in <i>P. falciparum</i>Semantic proximity Read ↗

Telomere length dynamics in response to DNA damage in malaria parasitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.