Article
Chromosome End Repair and Genome Stability in Plasmodium falciparum.
mBio - 8 Aug 2017
Calhoun Susannah F, Reed Jake, Alexander Noah, Mason Christopher E, Deitsch Kirk W, Kirkman Laura A
Abstract excerpt
The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost exclusively on homologous recombination (HR), due to a lack of efficient nonhomologous end joining. However, given that the parasite is haploid during this stage of its life...
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