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Article

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.

Nature methods - 1 Oct 2012

Straimer Judith, Lee Marcus C S, Lee Andrew H, Zeitler Bryan, Williams April E, Pearl Jocelynn R, Zhang Lei, Rebar Edward J, Gregory Philip D, Llinás Manuel, Urnov Fyodor D, Fidock David A

Abstract excerpt

Malaria afflicts over 200 million people worldwide, and its most lethal etiologic agent, Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics. Efficient tools for genome-directed investigations of P. falciparum-induced pathogenesis, including drug-resistance mechanisms, are clearly required. Here we report rapid and targeted genetic engineering of this parasite using zinc-finger...

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Identifiers

PMID: 22922501
DOI: 10.1038/nmeth.2143
PMCID: PMC3697006

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