Article
CCK Response Deficiency in Synphilin-1 Transgenic Mice.
PloS one - 1 Jan 2015
Smith Wanli W, Smith Megan, Yang Dejun, Choi Pique P, Moghadam Alexander, Li Tianxia, Moran Timothy H
Abstract excerpt
Previously, we have identified a novel role for the cytoplasmic protein, synphilin-1(SP1), in the controls of food intake and body weight in both mice and Drosophila. Ubiquitous overexpression of human SP1 in brain neurons in transgenic mice results in hyperphagia expressed as an increase in meal size. However, the mechanisms underlying this action of SP1 remain to be determined. Here we investigate a potential...
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