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Article

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.

Endocrinology - 1 Oct 2006

Kublaoui Bassil M, Holder J Lloyd, Tolson Kristen P, Gemelli Terry, Zinn Andrew R

Abstract excerpt

Single-minded 1 (SIM1) mutations are associated with obesity in mice and humans. Haploinsufficiency of mouse Sim1 causes hyperphagic obesity with increased linear growth and enhanced sensitivity to a high-fat diet, a phenotype similar to that of agouti yellow and melanocortin 4 receptor knockout mice. To investigate the effects of increased Sim1 dosage, we generated transgenic mice that overexpress human SIM1 and...

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Source

Identifiers

PMID: 16709610
DOI: 10.1210/en.2006-0453

Genes

SIM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.PMID 16709610Read ↗

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