Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis

29 Sept 2022

Abstract excerpt

MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched miRNA in the hypothalamus, causes obesity in mice. Targeted deletion of miR-7 in Single-minded homolog 1 (Sim1) neurons, a critical component of the hypothalamic melanocortin pathway, causes hyperphagia, obesity and increased linear growth,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to MicroRNA in disease regulation
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36175420
DOI: 10.1038/s41467-022-33367-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasisPMID 36175420Read ↗

MicroRNA-7a regulates pancreatic β cell functionSemantic proximity Read ↗

A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon SecretionSemantic proximity Read ↗

Cumulative Effects of Genetic Variants Detected in a Child with Early-Onset Non-Syndromic Obesity Due to SIM-1 Gene MutationSemantic proximity Read ↗

Forebrain neuronal SMC3 regulates body weight and metabolic health partially through regulation of hypothalamic Melanocortin 4 receptorSemantic proximity Read ↗

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.Semantic proximity Read ↗

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus NeuronsSemantic proximity Read ↗

The glypican 3-hosted murine mir717 gene: sequence conservation, seed region polymorphisms and putative targets.Semantic proximity Read ↗

Postnatal<i>Sim1</i>Deficiency Causes Hyperphagic Obesity and Reduced<i>Mc4r</i>and<i>Oxytocin</i>ExpressionSemantic proximity Read ↗

Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertilitySemantic proximity Read ↗

Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasisSemantic proximity Read ↗

Promoter or enhancer activation by CRISPRa rescues haploinsufficiency caused obesitySemantic proximity Read ↗

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.