Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenoviral-Mediated Modulation of<i>Sim1</i>Expression in the Paraventricular Nucleus Affects Food Intake

28 Jun 2006

Abstract excerpt

Haploinsufficency of Sim1, which codes for a basic helix-loop-helix-PAS (PER-ARNT-SIM) transcription factor, causes hyperphagia in mice and humans, without decrease in energy expenditure. Sim1 is expressed in several areas of the brain, including the developing and postnatal paraventricular nucleus (PVN), a region of the hypothalamus that controls food intake. We have previously found that the number of PVN cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Epigenetics and DNA Methylation
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16807340
DOI: 10.1523/jneurosci.0672-06.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenoviral-Mediated Modulation of<i>Sim1</i>Expression in the Paraventricular Nucleus Affects Food IntakePMID 16807340Read ↗

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamusSemantic proximity Read ↗

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus NeuronsSemantic proximity Read ↗

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.Semantic proximity Read ↗

<i>Sim1</i> gene dosage modulates the homeostatic feeding response to increased dietary fat in miceSemantic proximity Read ↗

Postnatal<i>Sim1</i>Deficiency Causes Hyperphagic Obesity and Reduced<i>Mc4r</i>and<i>Oxytocin</i>ExpressionSemantic proximity Read ↗

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene.Semantic proximity Read ↗

Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons.Semantic proximity Read ↗

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.Semantic proximity Read ↗

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesitySemantic proximity Read ↗

Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation.Semantic proximity Read ↗

Dmbx1 is essential in agouti-related protein action.Semantic proximity Read ↗

PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.