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Article

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2008

Kublaoui Bassil M, Gemelli Terry, Tolson Kristen P, Wang Yu, Zinn Andrew R

Abstract excerpt

Single-minded 1 (Sim1) encodes a transcription factor essential for formation of the hypothalamic paraventricular nucleus (PVN). Sim1 haploinsufficiency is associated with hyperphagic obesity and increased linear growth in humans and mice, similar to the phenotype of melanocortin 4 receptor (Mc4r) mutations. PVN neurons in Sim1(+/-) mice are hyporesponsive to the melanocortin agonist melanotan II. PVN...

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Identifiers

PMID: 18451093
DOI: 10.1210/me.2008-0067
PMCID: PMC2453606

Genes

CRH
TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.PMID 18451093Read ↗

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