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Article

Postnatal<i>Sim1</i>Deficiency Causes Hyperphagic Obesity and Reduced<i>Mc4r</i>and<i>Oxytocin</i>Expression

10 Mar 2010

Abstract excerpt

Single-minded 1 (SIM1) mutations are one of the few known causes of nonsyndromic monogenic obesity in both humans and mice. Although the role of Sim1 in the formation of the hypothalamus has been described, its postdevelopmental, physiological functions have not been well established. Here we demonstrate that postnatal CNS deficiency of Sim1 is sufficient to cause hyperphagic obesity. We conditionally deleted...

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PMID: 20220015
DOI: 10.1523/jneurosci.5444-09.2010

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