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Article

Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.

Nature communications - 16 Nov 2015

Caous Renaud, Pascal Aude, Romé Pierre, Richard-Parpaillon Laurent, Karess Roger, Giet Régis

Abstract excerpt

Tissue homeostasis requires accurate control of cell proliferation, differentiation and chromosome segregation. Drosophila sas-4 and aurA mutants present brain tumours with extra neuroblasts (NBs), defective mitotic spindle assembly and delayed mitosis due to activation of the spindle assembly checkpoint (SAC). Here we inactivate the SAC in aurA and sas-4 mutants to determine whether the generation of aneuploidy...

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Identifiers

PMID: 26568519
DOI: 10.1038/ncomms9879
PMCID: PMC4660220

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Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.PMID 26568519Read ↗

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