Article
Gender-related prognostic value and genomic pattern of intra-tumor heterogeneity in colorectal cancer.
Carcinogenesis - 1 Aug 2017
Zhang Jieyun, Yan Shican, Liu Xiyu, Gan Lu, Wu Zhenhua, Gong Yiwei, Huang Mingzhu, Zhang Xiaowei, Guo Weijian
Abstract excerpt
Intra-tumor heterogeneity (ITH) is crucial in tumorigenesis and resistance to target therapy. Here, we used mutant-allele tumor heterogeneity (MATH) to measure ITH based on next-generation sequencing data and high MATH was proven as an independent risk prognostic factor in male CRC patients in both a training set of 284 colorectal cancer (CRC) patients with from The Cancer Genome Atlas (TCGA) and a validating set...
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