Article
Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling.
American journal of physiology. Renal physiology - 1 Feb 2016
Tutakhel Omar A Z, Jeleń Sabina, Valdez-Flores Marco, Dimke Henrik, Piersma Sander R, Jimenez Connie R, Deinum Jaap, Lenders Jacques W, Hoenderop Joost G J, Bindels René J M
Abstract excerpt
The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. The human SLC12A3 gene, encoding NCC, gives rise to three isoforms. Only the third isoform has been extensively investigated. The aim of the present study was, therefore, to establish the abundance and localization of the almost identical isoforms 1 and 2 (NCC1/2) in the human kidney and to...
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