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Article

The evolving concepts of KS-WNK1 effect on NCC activity.

American journal of physiology. Renal physiology - 1 Feb 2025

Chávez-Canales María, Gamba Gerardo

Abstract excerpt

The field of the with-no-lysine kinases (WNKs) regulation of the thiazide-sensitive NaCl cotransporter (NCC) began at the start of the century with the discovery that mutations in two members of the family, WNK1 and WNK4, resulted in a condition known as familial hyperkalemic hypertension (FHHt). Since FHHt is the mirror image of Gitelman's syndrome that is caused by inactivating mutations of the SLC12A3 gene...

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Topics

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Share to WNK1 gene
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Share to Kidney Tubules, Distal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Serine-Threonine Kinases

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Source

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Identifiers

PMID: 39737691
DOI: 10.1152/ajprenal.00272.2024
PMCID: PMC12208112

Genes

WNK1
SLC12A3
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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