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Article

Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters.

Journal of hypertension - 1 Mar 2011

Acuña Rocío, Martínez-de-la-Maza Lilia, Ponce-Coria José, Vázquez Norma, Ortal-Vite Penélope, Pacheco-Alvarez Diana, Bobadilla Norma A, Gamba Gerardo

Abstract excerpt

OBJECTIVES: Screening for variants in SLC12A1 and SLC12A3 genes, encoding the renal Na:Cl (NCC) and Na:K:2Cl (NKCC2) cotransporters, respectively, in 3125 members of the Framingham Heart Study (FHS) revealed that carrying a rare mutation in one of these genes was associated with a significant red...

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Source

Identifiers

PMID: 21157372
DOI: 10.1097/HJH.0b013e328341d0fd

Genes

WNK3
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21157372-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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