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Article

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression.

Journal of the American Society of Nephrology : JASN - 1 Jun 2009

Glover Mark, Zuber Annie Mercier, O'Shaughnessy Kevin M

Abstract excerpt

Mutations in the WNK kinases WNK1 and WNK4 cause a rare familial form of hypertension (Gordon syndrome) by increasing expression of the thiazide-sensitive co-transporter NCCT in the kidney. Regulation of NCCT expression involves a scaffold of proteins composed of several kinases, including the third member of the WNK kinase family, WNK3. This protein, expressed in several tissues including kidney and brain,...

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Source

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Identifiers

PMID: 19470686
DOI: 10.1681/ASN.2008050542
PMCID: PMC2689907

Genes

WNK3
WNK4
WNK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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