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Article

Pathophysiological role of Na-Cl cotransporter in kidneys, blood pressure, and metabolism.

Human cell - 1 Sept 2024

You Ran, Jia Zhanjun

Abstract excerpt

The Na-Cl cotransporter (NCC) is a well-recognized regulator of ion transportation in the kidneys that facilitates Na+ reabsorption in the distal convoluted tubule. It is also the pharmacologic inhibitory target of thiazide diuretics, a class of front-line antihypertensive agents that have been widely used for decades. NCC is a potent regulator of Na+ reabsorption and homeostasis. Hence, its overactivation and...

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PMID: 38985392
DOI: 10.1007/s13577-024-01099-2

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