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Article

N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter.

Journal of the American Society of Nephrology : JASN - 1 Feb 2003

Hoover Robert S, Poch Esteban, Monroy Adriana, Vázquez Norma, Nishio Toshiyuki, Gamba Gerardo, Hebert Steven C

Abstract excerpt

The rat thiazide-sensitive Na-Cl cotransporter (rNCC) is expressed in the renal distal convoluted tubule and is the site of action of an important class of antihypertensive agents, the thiazide diuretics. The amino acid sequence contains two potential N-linked glycosylation consensus sites, N404...

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PMID: 12538726
DOI: 10.1097/01.asn.0000043903.93452.d0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12538726-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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