Article
The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer.
The Journal of biological chemistry - 4 Jul 2003
de Jong Joke C, Willems Peter H G M, Mooren Fieke J M, van den Heuvel Lambertus P W J, Knoers Nine V A M, Bindels René J M
Abstract excerpt
The thiazide-sensitive NaCl cotransporter (NCC) is responsible for the reabsorption of 5% of the filtered load of NaCl in the kidney. Mutations in NCC cause Gitelman syndrome. To gain insight into its regulation, detailed information on the structural composition of its functional unit is essential. Western blot analysis of total membranes of Xenopus laevis oocytes heterologously expressing FLAG-tagged NCC...
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