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Article

Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells.

American journal of physiology. Renal physiology - 1 Aug 2017

Rosenbaek Lena L, Rizzo Federica, MacAulay Nanna, Staub Olivier, Fenton Robert A

Abstract excerpt

The thiazide-sensitive sodium chloride cotransporter NCC is important for maintaining serum sodium (Na+) and, indirectly, serum potassium (K+) levels. Functional studies on NCC have used cell lines with native NCC expression, transiently transfected nonpolarized cell lines, or Xenopus laevis oocytes. Here, we developed the use of polarized Madin-Darby canine kidney type I (MDCKI) mammalian epithelial cell lines...

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Identifiers

PMID: 28515174
DOI: 10.1152/ajprenal.00088.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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