Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.

doi:10.1016/j.jaci.2015.09.026

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Article

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.

The Journal of allergy and clinical immunology - 1 May 2016

Machado Yoan, Freier Regina, Scheiblhofer Sandra, Thalhamer Theresa, Mayr Melissa, Briza Peter, Grutsch Sarina, Ahammer Linda, Fuchs Julian E, Wallnoefer Hannes G, Isakovic Almedina, Kohlbauer Vera, Hinterholzer Arthur, Steiner Markus, Danzer Martin, Horejs-Hoeck Jutta, Ferreira Fatima, Liedl Klaus R, Tollinger Martin, Lackner Peter, Johnson Christopher M, Brandstetter Hans, Thalhamer Josef, Weiss Richard

Abstract excerpt

BACKGROUND: The search for intrinsic factors, which account for a protein's capability to act as an allergen, is ongoing. Fold stability has been identified as a molecular feature that affects processing and presentation, thereby influencing an antigen's immunologic properties. OBJECTIVE: We assessed how changes in fold stability modulate the immunogenicity and sensitization capacity of the major birch pollen...

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Identifiers

PMID: 26559323
DOI: 10.1016/j.jaci.2015.09.026
PMCID: PMC4877439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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