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Article

Unlocking the allergenic structure of the major house dust mite allergen der f 2 by elimination of key intramolecular interactions.

FEBS letters - 3 Nov 2000

Takai T, Ichikawa S, Yokota T, Hatanaka H, Inagaki F, Okumura Y

Abstract excerpt

We report on the structural background of the remarkable reduction of allergenicity in engineering of the major house dust mite allergen Der f 2. Disruption of intramolecular disulfide bonds in Der f 2 caused extensive conformational change that was monitored by circular dichroism and gel-filtration analysis. The degree of conformational change correlated well with the degree of reductions in the capacity to bind...

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PMID: 11068041
DOI: 10.1016/s0014-5793(00)02096-2

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