Article
BALB/c-congenic ANP32B-deficient mice reveal a modifying locus that determines viability.
Experimental animals - 1 Jan 2016
Leo Vonny I, Bunte Ralph M, Reilly Patrick T
Abstract excerpt
We previously found that deletion of the multifunctional factor ANP32B (a.k.a. SSP29, APRIL, PAL31, PHAPI2) resulted in a severe but strain-specific defect resulting in perinatal lethality. The difficulty in generating an adult cohort of ANP32B-deficient animals limited our ability to examine adult phenotypes, particularly cancer-related phenotypes. We bred the Anp32b-null allele into the BALB/c and FVB/N genetic...
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