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Article

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.

Neuroscience research - 1 Oct 2010

Hadano Shinji, Yoshii Yasuhiro, Otomo Asako, Kunita Ryota, Suzuki-Utsunomiya Kyoko, Pan Lei, Kakuta Shigeru, Iwasaki Yasuo, Iwakura Yoichiro, Ikeda Joh-E

Abstract excerpt

Loss-of-function mutations in human ALS2 account for several juvenile recessive motor neuron diseases (MNDs). To understand the molecular basis underlying motor dysfunction in ALS2-linked MNDs, several lines of Als2(-/-) mice with a mixed genetic background were thus far generated, and their phenotypes were thoroughly characterized. However, several phenotypic discrepancies among different Als2-deficient lines...

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Source

Identifiers

PMID: 20558214
DOI: 10.1016/j.neures.2010.06.004

Genes

ALS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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