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Article

Strain background modifies phenotypes in the ATP8B1-deficient mouse.

PloS one - 1 Feb 2010

Shah Sohela, Sanford Ukina R, Vargas Julie C, Xu Hongmei, Groen Annamiek, Paulusma Coen C, Grenert James P, Pawlikowska Ludmila, Sen Saunak, Elferink Ronald P J Oude, Bull Laura N

Abstract excerpt

BACKGROUND: Mutations in ATP8B1 (FIC1) underlie cases of cholestatic disease, ranging from chronic and progressive (progressive familial intrahepatic cholestasis) to intermittent (benign recurrent intrahepatic cholestasis). The ATP8B1-deficient mouse serves as an animal model of human ATP8B1 deficiency. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effect of genetic background on phenotypes of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20126555
DOI: 10.1371/journal.pone.0008984
PMCID: PMC2813882

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Source receipt: pubmed, retrieved 7 Sept 2026.

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