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Article

Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.

Disease models & mechanisms - 1 Sept 2015

Jiang Shiming, Katz Tiffany A, Garee Jason P, DeMayo Francesco J, Lee Adrian V, Oesterreich Steffi

Abstract excerpt

Scaffold attachment factors SAFB1 and SAFB2 are multifunctional proteins that share >70% sequence similarity. SAFB1-knockout (SAFB1(-/-)) mice display a high degree of lethality, severe growth retardation, and infertility in male mice. To assess the in vivo role of SAFB2, and to identify unique functions of the two paralogs, we generated SAFB2(-/-) mice. In stark contrast to SAFB1(-/-), SAFB2(-/-) offspring were...

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Identifiers

PMID: 26092125
DOI: 10.1242/dmm.019885
PMCID: PMC4582101

Genes

SAFB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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