Article
Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype.
The Prostate - 1 Jun 2005
Williams Karin, Fernandez Suzanne, Stien Xavier, Ishii Kenichiro, Love Harold D, Lau Yun-Fai Chris, Roberts Richard L, Hayward Simon W
Abstract excerpt
BACKGROUND: We have sought to develop a new in vivo model of prostate carcinogenesis using human prostatic epithelial cell cultures. Human prostate cancers frequently display DNA amplification in the 8q24 amplicon, which leads to an increase in the copy number of the c-MYC gene, a finding that suggests a role for c-MYC in human prostate carcinogenesis. In addition overexpression of c-MYC in transgenic mouse...
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