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Article

A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53.

Oncogene - 19 Jan 2012

Kim J, Roh M, Doubinskaia I, Algarroba G N, Eltoum I-E A, Abdulkadir S A

Abstract excerpt

Human tumors are heterogeneous and evolve through a dynamic process of genetic mutation and selection. During this process, the effects of a specific mutation on the incipient cancer cell may dictate the nature of subsequent mutations that can be tolerated or selected for, affecting the rate at which subsequent mutations occur. Here we have used a new mouse model of prostate cancer that recapitulates several...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21685943
DOI: 10.1038/onc.2011.236
PMCID: PMC3179816

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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