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Article

Characterization of novel cell lines derived from a MYC-driven murine model of lethal metastatic adenocarcinoma of the prostate.

The Prostate - 1 Sept 2018

Markowski Mark C, Hubbard Gretchen K, Hicks Jessica L, Zheng Qizhi, King Alexia, Esopi David, Rege Apurv, Yegnasubramanian Srinivasan, Bieberich Charles J, De Marzo Angelo M

Abstract excerpt

BACKGROUND: Loss or mutation of PTEN alleles at 10q23 in combination with 8q24 amplification (encompassing MYC) are common findings in aggressive, human prostate cancer. Our group recently developed a transgenic murine model of prostate cancer involving prostate-specific Pten deletion and forced expression of MYC under the control of the Hoxb13 promoter. MYC overexpression cooperated with Pten loss to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 29851094
DOI: 10.1002/pros.23657
PMCID: PMC9844589

Genes

MYC
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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