Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.

Oncogene - 2 Aug 2012

Lu J, Hamze Z, Bonnavion R, Herath N, Pouponnot C, Assade F, Fontanière S, Bertolino P, Cordier-Bussat M, Zhang C X

Abstract excerpt

MafB, a member of the large Maf transcription factor family, is essential for the embryonic and terminal differentiation of pancreatic α- and β-cells. However, the role of MafB in the control of adult islet-cell proliferation remains unknown. Considering its oncogenic potential in several other tissues, we investigated the possible alteration of its expression in adult mouse β-cells under different conditions of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin B1
Share to Cyclin D2
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Insulin-Secreting Cells

Share to Insulinoma

Share to MafB Transcription Factor

Share to Pancreatic Neoplasms

Source

Identifiers

PMID: 22120711
DOI: 10.1038/onc.2011.538

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.PMID 22120711Read ↗

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cellsSemantic proximity Read ↗

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function PostnatallySemantic proximity Read ↗

Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.Semantic proximity Read ↗

Loss of the transcription factor MAFB limits β-cell derivation from human PSCsSemantic proximity Read ↗

MafB is required for islet beta cell maturation.Semantic proximity Read ↗

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.Semantic proximity Read ↗

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identitySemantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease OutcomesSemantic proximity Read ↗

Long Noncoding RNA Meg3 Regulates Mafa Expression in Mouse Beta Cells by Inactivating Rad21, Smc3 or Sin3αSemantic proximity Read ↗

Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.Semantic proximity Read ↗

Pancreatic β-cell specific loss of <i>E2f1</i> impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.