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Article

Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.

The Journal of biological chemistry - 15 Jan 2016

Musille Paul M, Kossmann Bradley R, Kohn Jeffrey A, Ivanov Ivaylo, Ortlund Eric A

Abstract excerpt

Phospholipids (PLs) are unusual signaling hormones sensed by the nuclear receptor liver receptor homolog-1 (LRH-1), which has evolved a novel allosteric pathway to support appropriate interaction with co-regulators depending on ligand status. LRH-1 plays an important role in controlling lipid and cholesterol homeostasis and is a potential target for the treatment of metabolic and neoplastic diseases. Although the...

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Identifiers

PMID: 26553876
DOI: 10.1074/jbc.M115.662874
PMCID: PMC4714224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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