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Article

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005

Wang Weiru, Zhang Chao, Marimuthu Adhirai, Krupka Heike I, Tabrizizad Maryam, Shelloe Rafe, Mehra Upasana, Eng Kevin, Nguyen Hoa, Settachatgul Calvin, Powell Ben, Milburn Michael V, West Brian L

Abstract excerpt

Steroidogenic factor-1 (SF-1) and liver receptor homologue-1 (LRH-1) belong to the fushi tarazu factor 1 subfamily of nuclear receptors. SF-1 is an essential factor for sex determination during development and regulates adrenal and gonadal steroidogenesis in the adult, whereas LRH-1 is a critical factor for development of endodermal tissues and regulates cholesterol and bile acid homeostasis. Regulatory ligands...

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Identifiers

PMID: 15897460
DOI: 10.1073/pnas.0409482102
PMCID: PMC1140416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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